Basic Information
VIS ID
TVIS30015068
Fusion event
HIV-FANCM integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
45622116/45152913 (Hg38)
End
45622277/45152913 (Hg38)
Orient
+
Location type
Intronic
Target gene
FANCM
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-192-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-573 ; hsa-mir-580-5p ; hsa-mir-889-3p ; hsa-mir-3120-3p ; hsa-mir-3616-5p ; hsa-mir-3908 ; hsa-mir-4795-5p ; hsa-mir-4803 ; hsa-mir-6772-3p ; hsa-mir-4268 ; hsa-mir-4448 ; hsa-mir-1976 ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-4532 ; hsa-mir-1247-3p ; hsa-mir-122-3p ; hsa-mir-146a-5p
Nearest miRNA
hsa-mir-208a/Upstream/8200522; hsa-mir-1185-1/Downstream/2608082;
Nearest TSS
ENST00000550708/Upstream/16399; ENST00000555013/Downstream/1846;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/16641, chr14-CpG: 69/Downstream/100032
Upstream sequence
ACCACGAAATGTGGTCTTTATCATATAGTATCTGGGGAAGCACTAAAGGAGTCTTTTCTGCaaaattatagtatattattatttaaaactttaaaaaGAT
Downstream sequence
AAACAGTAGTCTTCATCTCAAAGGAAAATAATTAGAATATGTTCTCCATGCTCTCCTTAAAAACTATCTTATCAGATAGATACACATACCATGTACTTCC
Target sequence
GTTTTGATTTCTGCTAGGAAATAGTAAATCTAAACCTGTTGAACTAGATCTTAACTGGAACTGGTGAGAGGTAATTAGGGTACCATTTTAGGGCATTTGTTAGTATCCTGGAATATTTAAAATCACTAACATTGATGTTAAGTGCTACTAAAAATGTTAGA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate