Basic Information
VIS ID
TVIS30015069
Fusion event
HIV-MAP4K5 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
50972868/50506150 (Hg38)
End
50972904/50506150 (Hg38)
Orient
+
Location type
Intronic
Target gene
MAP4K5
miRNAs that regulate target gene
hsa-mir-4639-5p ; hsa-mir-3121-5p ; hsa-mir-4667-3p ; hsa-mir-548at-5p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-548n
Nearest miRNA
hsa-mir-208a/Upstream/206204; hsa-mir-1185-1/Downstream/3442277;
Nearest TSS
ENST00000550708/Upstream/1022; ENST00000553509/Downstream/25937;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/108986, chr14-CpG: 109/Downstream/25709
Upstream sequence
TATGACCTTTTTCATTTACTATATTAGATTTGAATATCAACTTTCAAATGGCAGAAAAAAACAAGAAAAAGACATGATAAAATAGAAAAGTATAGTTATA
Downstream sequence
GAAAGAAGAGAAAAAGGGAAAGGAATAGAAGAATGATAAAGTAGGGAAGAGTGCCTTCAAAGAGATCCTTTTAAAAATGACATACAGAGGGTGAGAAAAA
Target sequence
CTAATCTGCCAAATTAAATAAATCAAATTTTCTGAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate