Basic Information
VIS ID
TVIS30015070
Fusion event
HIV-NIN integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
51242264/50775546 (Hg38)
End
51242170/50775546 (Hg38)
Orient
-
Location type
Intronic
Target gene
NIN
miRNAs that regulate target gene
hsa-mir-373-3p ; hsa-mir-148b-3p ; hsa-mir-375 ; hsa-mir-130b-3p ; hsa-mir-9-5p ; hsa-mir-192-5p ; hsa-mir-103a-3p ; hsa-mir-93-5p ; hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-18a-3p ; hsa-mir-125a-5p ; hsa-mir-4517 ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-6790-5p ; hsa-mir-4658 ; hsa-mir-222-5p ; hsa-mir-3659 ; hsa-mir-138-2-3p ; hsa-mir-574-5p ; hsa-mir-545-5p ; hsa-mir-4719 ; hsa-mir-205-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-4796-3p ; hsa-mir-519a-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-208a/Upstream/475600; hsa-mir-1185-1/Downstream/3172881;
Nearest TSS
ENST00000550708/Upstream/2548; ENST00000555966/Downstream/18972;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/106960, chr14-CpG: 179/Downstream/54463
Upstream sequence
ctaaaatggcgttcagttgtaaaattttaggattccaAGTAAATGAGATCATCTTGAACTTCCAGCTCCTCTGTGGTTTAGAGCTAGTAATACTAAGTAC
Downstream sequence
TATAGAATTTCACTATTTTTCTTTAGCAGGAAAAACACTAAGTAAAAGTTATATTCTATGAGCAATCCTCTACTTGTCCTCAGGCCAGAGGAAAATAACT
Target sequence
tggcgttcagttgtaaaattttaggattccaAGTAAATGAGATCATCTTGAACTTCCAGCTCCTCTGTGGTTTAGAGCTAGTAATACTAAGTAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate