Basic Information
VIS ID
TVIS30015071
Fusion event
HIV-ERO1A integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
53124840/52658122 (Hg38)
End
53124973/52658122 (Hg38)
Orient
+
Location type
Intronic
Target gene
ERO1A
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-let-7b-5p ; hsa-mir-296-3p ; hsa-mir-106b-5p ; hsa-mir-182-5p ; hsa-mir-3653-3p ; hsa-mir-203a-5p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-4698 ; hsa-mir-4433b-3p ; hsa-mir-548p ; hsa-mir-6821-5p ; hsa-mir-7977 ; hsa-mir-1268b ; hsa-mir-1268a ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-583 ; hsa-mir-6089 ; hsa-mir-4683 ; hsa-mir-6781-3p ; hsa-mir-2682-3p ; hsa-mir-494-3p ; hsa-mir-664a-5p ; hsa-mir-4794 ; hsa-mir-8073 ; hsa-mir-221-5p ; hsa-mir-4793-5p ; hsa-mir-6890-3p ; hsa-mir-6888-5p ; hsa-mir-6502-3p ; hsa-mir-433-5p ; hsa-mir-200a-3p ; hsa-mir-141-3p ; hsa-let-7a-5p ; hsa-let-7c-5p ; hsa-let-7d-5p ; hsa-let-7e-5p ; hsa-let-7f-5p ; hsa-let-7g-5p ; hsa-let-7i-5p ; hsa-mir-2054 ; hsa-mir-338-5p ; hsa-mir-4458 ; hsa-mir-4462 ; hsa-mir-4500 ; hsa-mir-582-5p ; hsa-mir-6504-3p
Nearest miRNA
hsa-mir-208a/Upstream/2358176; hsa-mir-1185-1/Downstream/1290305;
Nearest TSS
ENST00000550708/Upstream/10998; ENST00000553798/Downstream/419;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/104626, chr14-CpG: 97/Downstream/36998
Upstream sequence
GTGACTTAGAAATAAAATTTCATATGTGAATCTTGTAGACATAAAATTAATCTCATGAGAAAAAAACCATCATTGAAATTTATTTTAAAGTTTCTAATTA
Downstream sequence
AAGATTATTTAACCTAACGGTCCAAGTCTTAATTGCAATTTCTCGAAAGGAAGAAGAAAGGTTATGGATTCAGTTAAGTACCAGCCTGCTGCTTGGTCTT
Target sequence
CCTTCTAGCCAACTGTAAAAAGTGTTCTCTGAAATCAAAAGAAAAATAAGTCATAAGAATAGAAAAATGCCAAAATACAAGTTTTTCAAAAGTTTTAAAGCATTATAGCAAATTTGTGCCAAACAACAATGTA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate