Basic Information
VIS ID
TVIS30015074
Fusion event
HIV-ARID4A integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
58792867/58326149 (Hg38)
End
58792756/58326149 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA14B
Target gene
ARID4A
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-548as-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-6771-3p
Nearest miRNA
hsa-mir-208a/Upstream/3447956; hsa-mir-1185-1/Downstream/1320813;
Nearest TSS
ENST00000550708/Upstream/26612; ENST00000553355/Downstream/5138;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/26481, chr14-CpG: 70/Downstream/69674
Upstream sequence
tttatttgaggaaaatacagaaagccttcacaaagcaggtgcttttgaggtgagctttgaaggatTTAAAGATAGTAGGCAAAGCTTCACTAGAGGAAAC
Downstream sequence
AAAAAAATAGGTTAAAAAAATAGcatgcctgtaatcccagcactttgggaggctgaggtgggcagatcacgaggtcaggagatcgagaccatcctggcta
Target sequence
gagagattacatttatttgaggaaaatacagaaagccttcacaaagcaggtgcttttgaggtgagctttgaaggatTTAAAGATAGTAGGCAAAGCTTCACTAGAGGAAAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate