Basic Information
VIS ID
TVIS30015076
Fusion event
HIV-SGPP1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
64174669/63707951 (Hg38)
End
64174643/63707951 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA14B
Target gene
SGPP1
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-215-5p ; hsa-mir-34a-5p ; hsa-mir-192-5p ; hsa-mir-92b-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-208a/Upstream/3059240; hsa-mir-1185-1/Downstream/387073;
Nearest TSS
ENST00000550708/Upstream/65808; ENST00000556725/Downstream/20088;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/65717, chr14-CpG: 82/Downstream/19572
Upstream sequence
AAATCCCTATTCAAACCTCCAGGGTTGAGAACAAATCTAGTCTGTGGTGACAATAGTTGTATAGCTGCCTCGGCACTCAGGAAAAAGTGAGTGTGGTAGG
Downstream sequence
CTCATTAAGTACAATAATTTTCAAAATGCAAAACGCATTACAATGGCAAACTCAAATTCTGTCTTTCCCACATTAGTAAATTTAGCAATTCTGTAAGAGC
Target sequence
ACTCAGGAAAAAGTGAGTGTGGTAGG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate