Basic Information
VIS ID
TVIS30015079
Fusion event
HIV-CHURC1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
65385774/64919056 (Hg38)
End
65385700/64919056 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA14B
Target gene
CHURC1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-93-5p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-208a/Upstream/133370; hsa-mir-1185-1/Downstream/125632;
Nearest TSS
ENST00000550708/Upstream/4563; ENST00000547625/Downstream/4954;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/4392, chr14-CpG: 81/Downstream/52638
Upstream sequence
CAGACTAGAAATATATAGTACTGAATTCTTAATGGGGCTCTGGCCTACTTGCTTATACTGTTAACACTGAGAATTTGAATTCAAACATGAGTCAAGTTGG
Downstream sequence
AATGAACCATACTAATTTTCTGAACCCAAATGTTTTTTAACTCAATGGTGAACCACATTTTTTTTTTCCTTCAGAAAAGCATTTAGCAAACCAGTCAGAA
Target sequence
TCTTAATGGGGCTCTGGCCTACTTGCTTATACTGTTAACACTGAGAATTTGAATTCAAACATGAGTCAAGTTGG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate