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TVIS30015080
Basic Information
VIS ID
TVIS30015080
Fusion event
HIV-MPP5 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
67785089/67318372 (Hg38)
End
67784907/67318372 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA14B
Target gene
MPP5
miRNAs that regulate target gene
hsa-mir-375
;
hsa-mir-130b-3p
;
hsa-mir-155-5p
;
hsa-mir-7-5p
;
hsa-mir-148a-3p
;
hsa-mir-192-5p
;
hsa-mir-21-5p
;
hsa-mir-93-3p
;
hsa-mir-302a-3p
;
hsa-mir-302b-3p
;
hsa-mir-302c-3p
;
hsa-mir-302d-3p
;
hsa-mir-372-3p
;
hsa-mir-373-3p
;
hsa-mir-520e
;
hsa-mir-519c-3p
;
hsa-mir-520a-3p
;
hsa-mir-519b-3p
;
hsa-mir-520b
;
hsa-mir-520c-3p
;
hsa-mir-520d-3p
;
hsa-mir-519a-3p
;
hsa-mir-548a-3p
;
hsa-mir-548e-3p
;
hsa-mir-548f-3p
;
hsa-mir-302e
;
hsa-mir-4639-5p
;
hsa-mir-548ar-3p
;
hsa-mir-548az-3p
;
hsa-mir-6074
;
hsa-mir-374b-5p
;
hsa-mir-374a-5p
;
hsa-mir-6817-5p
;
hsa-mir-4769-3p
;
hsa-mir-6727-3p
;
hsa-mir-4722-3p
;
hsa-mir-5683
;
hsa-mir-181d-5p
;
hsa-mir-181c-5p
;
hsa-mir-181a-5p
;
hsa-mir-181b-5p
Nearest miRNA
hsa-mir-208a/Upstream/1847186; hsa-mir-1185-1/Downstream/123483;
Nearest TSS
ENST00000550708/Upstream/76745;
ENST00000556724/Downstream/19404;
Nearest CpG islands
None/Target,
chr14-CpG: 35/Upstream/76442
,
chr14-CpG: 97/Downstream/41050
Upstream sequence
CATTATAATATTCCATAAAAGCTAAATGAGGTTTGATCAACtttaataaatttttttctaaaataaatatCCTTTAATGCTAATTGACAGATTATGTAAC
Downstream sequence
TAAAAAGATTTAATGAGTTTTAAATTTTATCCTCTATATTTGTGATTAATATCTCTTTTATTTTTTGAAACAGACTGAAGTTAACTAGTCCAGCTCTAAG
Target sequence
AATTTATAAGGCTTTTCTGTCAAGAATTTGAAATATTTGGGAGCAGCACACATTAAACTAATAAAGATAAAACATTATAGATCATTATAATATTCCATAAAAGCTAAATGAGGTTTGATCAACtttaataaatttttttctaaaataaatatCCTTTAATGCTAATTGACAGATTATGTAAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT1
Sample type
PBMC
Age
47
Gender
Male
CpG Island Information
×
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