Basic Information
VIS ID
TVIS30015082
Fusion event
HIV-RAD51B integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
68441816/67975099 (Hg38)
End
68441899/67975099 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA14C
Target gene
RAD51B
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-4668-5p ; hsa-mir-2053 ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-30b-3p ; hsa-mir-3689a-3p ; hsa-mir-1273h-5p ; hsa-mir-569 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-766-5p ; hsa-mir-6871-5p ; hsa-mir-4496 ; hsa-mir-4506
Nearest miRNA
hsa-mir-208a/Upstream/533169; hsa-mir-1185-1/Downstream/4541721;
Nearest TSS
ENST00000550708/Upstream/66794; ENST00000554575/Downstream/25180;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/299934, chr14-CpG: 40/Downstream/653199
Upstream sequence
GGAGAGTTGATATCTGCTTTGCTGGCTTCACATCtgtattagttatcaattgccataacaaattaccctaaaacttagccgctttaaacaatgaacattt
Downstream sequence
TATTATTGAATGGTGCACAAATGAATGCTGTTATTCAAGTTGAGGTTCTTATCACTTAGCACCTAATGGGCTCCACCATCTTCTTTGCTGGCTTCCAATC
Target sequence
attacctaatggtttctgtgggctagtaatATCGTATCTGTCTTATTCACATGTGAATGATGAACATTCAGACATCCGATAAA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate