Basic Information
VIS ID
TVIS30015084
Fusion event
HIV-PCNX1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
71394997/70928280 (Hg38)
End
71394953/70928280 (Hg38)
Orient
-
Location type
Intronic
Target gene
PCNX1
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-17-5p ; hsa-mir-3941 ; hsa-mir-374a-5p ; hsa-mir-510-3p ; hsa-mir-6831-3p ; hsa-mir-4637 ; hsa-mir-590-3p ; hsa-mir-4282 ; hsa-mir-2355-3p ; hsa-mir-4646-3p ; hsa-mir-3912-5p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-5688 ; hsa-mir-495-3p
Nearest miRNA
hsa-mir-208a/Upstream/3486350; hsa-mir-1185-1/Downstream/1588540;
Nearest TSS
ENST00000550708/Upstream/20541; ENST00000553508/Downstream/18602;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/19595, chr14-CpG: 116/Downstream/391858
Upstream sequence
GCAAGGAGAATCTCATTGTTTTTAATGTATTTGCTCATAAGGTAATCCCATTAAATGTATCCTGAACTGGCATTTTGTGAGGTATGTTAAAACAATAACC
Downstream sequence
TAGCTGCTATTCTTCAGAATTGCAGTGTCATGTTGACAGAATTTGTTAATGAATGCTTACTTTTACTTAATTGTGAATCCTGAAAAAATGTTGCAATAGA
Target sequence
GTATCCTGAACTGGCATTTTGTGAGGTATGTTAAAACAATAACC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate