Basic Information
VIS ID
TVIS30015094
Fusion event
HIV-CPSF2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.12
Reference genome
GRCh37/hg19
Start
92603958/92137614 (Hg38)
End
92604116/92137614 (Hg38)
Orient
+
Location type
Intronic
Target gene
CPSF2
miRNAs that regulate target gene
hsa-mir-193a-3p ; hsa-mir-4436b-3p ; hsa-mir-4480 ; hsa-mir-3185 ; hsa-mir-873-5p ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-6165 ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-7977 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-5008-5p ; hsa-mir-5693 ; hsa-mir-3937 ; hsa-mir-383-3p ; hsa-mir-4519 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-4767
Nearest miRNA
hsa-mir-1260a/Upstream/14871324; hsa-mir-1185-1/Downstream/1810612;
Nearest TSS
ENST00000550708/Upstream/15629; ENST00000556622/Downstream/16407;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/14936, chr14-CpG: 140/Downstream/185432
Upstream sequence
ATTTTTAAATGGTGATTTTCTTCTGGGAAGTATGTAGAATTGGTCAGTCTTTTTGATTGAACTTTTCTGGATGAGGTTAAATCTTGCTGGAAAGCCTTTT
Downstream sequence
gtgtagacacaataaaatgtttttataactgttaaacatttagtttagaaaaaaatttttatgtcctgggtaaaaaccaggatatagaactgagcgtata
Target sequence
AGCAGTACTATGTATTAAcagtaaatacatttttaggaatgtgacctaaagaaacaatcagaaatgcaattgaagcttttgtaaaaaatgttctttggaagattataatggcaaaaataagtgaccgaaatatcagtaaagggaaaggatcaaataca
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate