Basic Information
VIS ID
TVIS30015096
Fusion event
HIV-VRK1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
97296489/96830152 (Hg38)
End
97296539/96830152 (Hg38)
Orient
+
Location type
Intronic
Target gene
VRK1
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-mir-4693-3p ; hsa-mir-4694-3p ; hsa-mir-3662
Nearest miRNA
hsa-mir-1260a/Upstream/1692166; hsa-mir-1185-1/Downstream/3279267;
Nearest TSS
ENST00000550708/Upstream/32767; ENST00000557352/Downstream/22736;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/32250, chr14-CpG: 54/Downstream/203116
Upstream sequence
tttcccctggcataaaatgttgctgttaaagtgatgacaatttgattttattttccttataaaatatctgcagatgctcaaaaagtattttcatttacta
Downstream sequence
caaatgtatgtgatatgacctttcaaaatgtagttttatgtttaaatgaagttcaggaaagttttcttgaattaaatgatttttaatattctgttccctt
Target sequence
ttaagttaactaaattatatcttggtgatggtcattctgggttgattttt
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate