VISDB - VIS Detail

Basic Information

VIS ID

TVIS30015098

Fusion event

HIV-BCL11B integration

Validated

Yes

Detection method

LM PCR

Data source

Curated

Sample type

PBMC

Disease

HIV-infected disease (HID)

Quality evaluation

Good

Reported year

2014

PubMed ID

24968937

Virus Sequence

Virus name

HIV

Reference genome

Not given

Host Sequence

Chromosome

chr14

Cytoband

q32.2

Reference genome

GRCh37/hg19

Start

99695552/99229215 (Hg38)

End

99696047/99229215 (Hg38)

Orient

Location type

Intronic

Target gene

BCL11B

miRNAs that regulate target gene

hsa-mir-186-5p ; hsa-mir-128-3p ; hsa-mir-183-5p ; hsa-mir-32-5p ; hsa-mir-26b-5p ; hsa-mir-16-5p ; hsa-mir-203a-3p ; hsa-mir-137 ; hsa-mir-552-5p ; hsa-mir-218-5p ; hsa-mir-6508-3p ; hsa-mir-4640-5p ; hsa-mir-4726-5p ; hsa-mir-3926 ; hsa-mir-378g ; hsa-mir-4486 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-330-5p ; hsa-mir-326 ; hsa-mir-1224-3p ; hsa-mir-1273d ; hsa-mir-4311 ; hsa-mir-944 ; hsa-mir-367-3p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-25-3p ; hsa-mir-363-3p ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-2276-3p ; hsa-mir-4772-3p ; hsa-mir-330-3p ; hsa-mir-8070 ; hsa-mir-8066 ; hsa-mir-3119 ; hsa-mir-4713-5p ; hsa-mir-642a-5p ; hsa-mir-2116-3p ; hsa-mir-532-3p ; hsa-mir-150-5p ; hsa-mir-6832-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-3938

Nearest miRNA

hsa-mir-1260a/Upstream/4091229; hsa-mir-1185-1/Downstream/880204;

Nearest TSS

ENST00000550708/Upstream/70799; ENST00000429450/Downstream/33733;

Nearest CpG islands

None/Target, chr14-CpG: 35/Upstream/52785, chr14-CpG: 133/Downstream/16287

Nearest cancer related gene

BCL11B(OG, No orient, 0)

Upstream sequence

atgaatggatggatggatggatggatggatggatggatggaCGGACGGATAGACGTGAGCTGTGAGAactcaacatctctgaacatcattttctcatctg

Downstream sequence

GATTTCTGTGCCACGGAACTTGACCGCGTCCAGTAATAAACACTCAGGCTGATCTTCGATAGCATGGCCCCCCCAGTGGTTGCCGAGGCTGCAGCGCTAA

Target sequence

caaagtgaggagaataaagtattagggttgctgtgagggttaaattcaagaaggcacacatgcccagcacaatgcagcacatagcaggccctccatacacagtCCTCATAAGGATCCTAGTGGCATGTATGAGGACTTGCTGATGGCAGAGCCCCCCAGAGCCAAGGCAGTGGAAAGCTCATTCGACCTCCCGTGGATGTCGGCAgaggcagcgtggctccacaggaagaggggtggcctttcaggaggcaacca

Reference

Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.