Basic Information
VIS ID
TVIS30015101
Fusion event
HIV-PPP2R5C integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.31
Reference genome
GRCh37/hg19
Start
102288207/101821870 (Hg38)
End
102288303/101821870 (Hg38)
Orient
+
Location type
Intronic
Target gene
PPP2R5C
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-30a-5p ; hsa-mir-31-3p ; hsa-mir-135b-5p ; hsa-mir-15a-5p ; hsa-mir-103a-3p ; hsa-mir-107 ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-1277-5p ; hsa-mir-3190-3p ; hsa-mir-3607-5p ; hsa-mir-3611 ; hsa-mir-4524a-5p ; hsa-mir-5011-5p ; hsa-mir-4524b-5p ; hsa-mir-6505-5p ; hsa-mir-6833-5p ; hsa-mir-6838-5p ; hsa-mir-7114-5p ; hsa-mir-29c-5p ; hsa-mir-4680-5p ; hsa-mir-134-3p ; hsa-mir-646 ; hsa-mir-503-5p ; hsa-mir-3664-5p ; hsa-mir-548ao-3p ; hsa-mir-193b-3p ; hsa-mir-193a-3p
Nearest miRNA
hsa-mir-1185-1/Upstream/261448; hsa-mir-12121/Downstream/717774;
Nearest TSS
ENST00000550708/Upstream/11549; ENST00000607042/Downstream/1783;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/39928, chr14-CpG: 17/Downstream/69680
Nearest cancer related gene
PPP2R5C(TSG, No orient, 0)
Upstream sequence
GCGGCAAGTGGAAGGTGGAGCTGTCACAGACACTCGGCCCCCGCAGCCTGTGCATAGGTGCTCTAGGCTAATTTTACAGGTGTGATGACCGGGCCAGAGT
Downstream sequence
TGAGGAGATGTTTCCCTTTAGAGAACATCATTGACGCTTTTAAGAGTATTTTACTAGATGTTGAAAACGTTGAGGTCTTATTAATGTAGTGACCCCACCA
Target sequence
GAAACCATGTTGTCTGATTTTAGAACAGAGGTCACTTATGCTTCACCAAGCTGCTGGAAATGTGGAATTTTGTTTCTCAATTATTGGACCTGGTCC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate