Basic Information
VIS ID
TVIS30015116
Fusion event
HIV-PAK6 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q15.1
Reference genome
GRCh37/hg19
Start
40513337/40221136 (Hg38)
End
40513389/40221136 (Hg38)
Orient
+
Location type
Intronic
Target gene
PAK6
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-8485 ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-7156-5p ; hsa-mir-4273 ; hsa-mir-6873-3p ; hsa-mir-2117 ; hsa-mir-6845-3p ; hsa-mir-3686 ; hsa-mir-3607-3p ; hsa-mir-136-5p ; hsa-mir-4778-5p ; hsa-mir-4796-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-466 ; hsa-mir-4672
Nearest miRNA
hsa-mir-1233-1/Upstream/3248235; hsa-mir-10393/Downstream/1470449;
Nearest TSS
ENST00000557528/Upstream/2636; ENST00000560806/Downstream/17623;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/59641, chr15-CpG: 32/Downstream/17907
Upstream sequence
TCCCTGTACTTTTCCCATTTGTAATTTGTAAAATGTTCTCTTATGATCACCATGTATTTTGTAAATAATAAAATAGTATCTGTTAAATTTGTGCTTCTAA
Downstream sequence
GATGAACTATTTTGCCATGGAAATTTATATATCCTAGACTTCGAATTGTTACAATAGGGTTGTGATGAGACAGAGTAGCCAACTATTTCTTTAGGTGGGT
Target sequence
CATGTCATGTAGTTTTTGCAAACTAAAATAACAGATGGCTTAACTTTGCAGA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate