Basic Information
VIS ID
TVIS30015118
Fusion event
HIV-MGA integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q15.1
Reference genome
GRCh37/hg19
Start
41972653/41680455 (Hg38)
End
41972758/41680455 (Hg38)
Orient
+
Location type
Intronic
Target gene
MGA
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-21-5p
Nearest miRNA
hsa-mir-1233-1/Upstream/4707554; hsa-mir-10393/Downstream/11130;
Nearest TSS
ENST00000557528/Upstream/10731; ENST00000566288/Downstream/54099;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/18315, chr15-CpG: 63/Downstream/93835
Upstream sequence
CAATTTAAAAAATTAAGTAAAAATAGTACTATTCTGTTTTAACCCCCCCTGATGCATTGAATAAGAACCCATAGTTGGTCTccataggttgaaatgcatg
Downstream sequence
tctctcaggttcactaattcactagactcatagaactcaggaaaacactgtatttagaattagaattttgctgtaaagaatacaagttaggaccagccta
Target sequence
gtccccaacaagactgcacctagttgagacattaaccacaactggagatcctaggccacctgtacttttcaccagttggctacaaatcctgagattctcacaatc
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate