Basic Information
VIS ID
TVIS30015119
Fusion event
HIV-MGA integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q15.1
Reference genome
GRCh37/hg19
Start
42031493/41739295 (Hg38)
End
42031106/41739295 (Hg38)
Orient
-
Location type
Intronic
Target gene
MGA
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-21-5p
Nearest miRNA
hsa-mir-1233-1/Upstream/47617; hsa-mir-10393/Downstream/127200;
Nearest TSS
ENST00000557528/Upstream/4741; ENST00000566288/Downstream/9436;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/77155, chr15-CpG: 63/Downstream/34995
Upstream sequence
GATAAACTCAGGCAGCAGAGGGGATCTTTACTTCATTTGTTGGTTCACTTTCTTCTGACTATTTAGTTAATTATGTCTAGAATAAGAATGAGTTCGTACC
Downstream sequence
AACATTCAGTTTGAACCCATGTTTTATCCAAGAGATGAAAATAGTATTTTCAAAGCTAAGCTTTTTGAAAATGAAAAACTGTGAGGTAATTGTGGCTTAG
Target sequence
ATTTTGTTTTGTGTCTCTGAAGATGGAGTTGCTTGCTGTAGCTGGTCTCCTCACCAGTTCCCTGTTAGAGAGTAGATTCTACCTCACTCCATCTCCCCCAACCCCCGATTTTGAAATGGTGAAAAGGAAATATAGAAAAGGTTATCTTCTCTAGAGTTGCCTGGCAATATGACCTAGAGAACATGGGTAGAGACTTGGGAAGTTTTTGTTTTCTTTCTTTAAAAAAAAAAGAAAAGAAATCAACCCCCACAAAAA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate