Basic Information
VIS ID
TVIS30015121
Fusion event
HIV-SPG11 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
44907163/44614965 (Hg38)
End
44907058/44614965 (Hg38)
Orient
-
Location type
Intronic
Target gene
SPG11
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-22-3p
Nearest miRNA
hsa-mir-1233-1/Upstream/821206; hsa-mir-10393/Downstream/102879;
Nearest TSS
ENST00000557528/Upstream/4106; ENST00000632133/Downstream/5340;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/77214, chr15-CpG: 63/Downstream/48128
Upstream sequence
GATTCTGCGGGTTAATCTTAGGCAGACAGATACTAATGTATTGCTCTCTCTTTCTCTGTGCGTGTGTGTGTCTATAGAAATATAAATTTTAGAGCATATC
Downstream sequence
TAATATACCTTGAAAGTGAAATACAGTTTGCTATGAAATCAAAGTTGCTTAGCATTCTCTTGGTAATCAAAGTATCAAAGAAAACTCCAAGTAAAACTTT
Target sequence
GATATGATTCTGCGGGTTAATCTTAGGCAGACAGATACTAATGTATTGCTCTCTCTTTCTCTGTGCGTGTGTGTGTCTATAGAAATATAAATTTTAGAGCATATC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate