Basic Information
VIS ID
TVIS30015123
Fusion event
HIV-PATL2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
44962782/44670584 (Hg38)
End
44962399/44670584 (Hg38)
Orient
-
Location type
Intronic
Target gene
PATL2
Nearest miRNA
hsa-mir-1233-1/Upstream/876825; hsa-mir-10393/Downstream/47260;
Nearest TSS
ENST00000557528/Upstream/2099; ENST00000632133/Downstream/5035;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/6799, chr15-CpG: 72/Downstream/40678
Upstream sequence
cccagACAAGCACGGCCTCTTAACACTCTTTCCTACAACAATCATTCCAGAAATGATGCTGGCACCTTAGGCCCTCCTTGCAGTTATTCTAAAGTGTCTT
Downstream sequence
AAGCACCCTGGGCCCCACATCACCCATCTTGGAATTCACATACCAAATACTTAAAGACCAGATACCACCACCAAGTCTGATGAAAGGTCAGAGAGCAAAG
Target sequence
ATAAGttttgttgtttgagacagcatctccctctgtcacccagctggagtgcagtggcgcaatctctggctcactgcaacctccctggctcaagtgatcctcccacttcagcctcctcagtagctggggccacaggcacgtgccaccatgcccagctaatttttgtattttttgtagaggtgggatttcaccatgttgctcaggctggtcttgaactcctggactcaagcaatcagccctccttggcctcccaaa
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate