Basic Information
VIS ID
TVIS30015126
Fusion event
HIV-GALK2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
49464553/49172356 (Hg38)
End
49464516/49172356 (Hg38)
Orient
-
Location type
Intronic
Target gene
GALK2
miRNAs that regulate target gene
hsa-mir-148a-5p ; hsa-mir-4474-5p ; hsa-mir-3613-3p ; hsa-mir-500a-5p ; hsa-mir-4668-3p ; hsa-mir-548c-3p ; hsa-mir-421 ; hsa-mir-4709-5p ; hsa-mir-34c-3p
Nearest miRNA
hsa-mir-10393/Upstream/3203; hsa-mir-11181/Downstream/1187973;
Nearest TSS
ENST00000557528/Upstream/1878; ENST00000561014/Downstream/66864;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/16486, chr15-CpG: 54/Downstream/448432
Upstream sequence
GTTCTTCTTGCTTTTCATGATTTTTATATTATTCATGTAACAAATATTTATTGTTAATATTTATTCTGTGTTATCCACAgaagagatcatagtagataag
Downstream sequence
ctctgccgttttcttgtttttcatttgtgcacaaaatgcaattattagcttcaagcaatgttttatttgcaggaatgttttgcagccacttactcattct
Target sequence
TTCTGTGTTATCCACAgaagagatcatagtagataag
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate