Basic Information
VIS ID
TVIS30015127
Fusion event
HIV-ATP8B4 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
50361227/50069030 (Hg38)
End
50361198/50069030 (Hg38)
Orient
-
Location type
Intronic
Target gene
ATP8B4
miRNAs that regulate target gene
hsa-mir-5585-3p ; hsa-mir-6857-3p ; hsa-mir-6761-5p ; hsa-mir-4494 ; hsa-mir-208a-5p ; hsa-mir-208b-5p ; hsa-mir-4499 ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p
Nearest miRNA
hsa-mir-10393/Upstream/899877; hsa-mir-11181/Downstream/291299;
Nearest TSS
ENST00000557528/Upstream/21643; ENST00000559938/Downstream/44286;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/447745, chr15-CpG: 86/Downstream/113095
Upstream sequence
ACTGTTTTCACCACTTCTACCATTCACTCTGAAATCCTTTTAACAGGAATGAGTCTGGCTGTTTGGCTCACTCACAATTTTTCTTTTAACAATTATTAAC
Downstream sequence
ATTAACATATTTTAAAACAACTGTTTTCTACTTCTATTATTCATTCCTATTATTAACCAAGAAAACATTGAACTCCCTTCTAATGAGAATAATTCTTCTA
Target sequence
TCACAATTTTTCTTTTAACAATTATTAAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate