Basic Information
VIS ID
TVIS30015128
Fusion event
HIV-AP4E1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
51218975/50926778 (Hg38)
End
51219000/50926778 (Hg38)
Orient
+
Location type
Intronic
Target gene
AP4E1
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-6509-5p ; hsa-mir-331-5p ; hsa-mir-6729-5p ; hsa-mir-4649-5p ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-922 ; hsa-mir-759 ; hsa-mir-3936
Nearest miRNA
hsa-mir-10393/Upstream/566368; hsa-mir-11181/Downstream/315412;
Nearest TSS
ENST00000557528/Upstream/11222; ENST00000561397/Downstream/70971;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/17705, chr15-CpG: 136/Downstream/166886
Upstream sequence
acctctgcctcccgggttcaagctattcttctgcctcagcctcctgagtagttggaactacaggcgcccgccactatgcctggctaatgttttagtagag
Downstream sequence
ctggtctcgaactcctgacctcgtgatccacctgtcttggcctcccaaagtgctgggcttacaggcgtgagccaccatgcccggccAACTTGTATACTTT
Target sequence
acagtgtttcaccatataggccaag
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate