Basic Information
VIS ID
TVIS30015129
Fusion event
HIV-GNB5 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
52435273/52143076 (Hg38)
End
52435356/52143076 (Hg38)
Orient
+
Location type
Intronic
Target gene
GNB5
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-128-3p ; hsa-mir-148a-3p ; hsa-mir-27a-3p ; hsa-mir-26b-5p ; hsa-mir-425-5p ; hsa-mir-6807-5p ; hsa-mir-1292-3p ; hsa-mir-4279 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-4722-3p ; hsa-mir-6727-3p ; hsa-mir-6877-3p ; hsa-mir-6819-3p ; hsa-mir-5089-5p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6778-3p ; hsa-mir-4707-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-150-5p ; hsa-mir-7107-5p ; hsa-mir-1234-3p ; hsa-mir-186-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-512-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p
Nearest miRNA
hsa-mir-10393/Upstream/828967; hsa-mir-11181/Downstream/134041;
Nearest TSS
ENST00000557528/Upstream/1865; ENST00000559779/Downstream/1385;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/30295, chr15-CpG: 100/Downstream/36307
Upstream sequence
aaaccccatctctactaaaaatacaaaaattagctgggcaaggtggcaggtgcctgtaatcccagctacttgggaggctgaggcaggagaattgcttgaa
Downstream sequence
aaaagagaaaaaaaaaaaaCAGAATGTGTAGAGAATGATTTGCACTTAGGCTATGGTAAGGGGACAAGCATGCTGTGGACTATGGTCCTCCCTGACCCCT
Target sequence
cctgggaggtggaggttgcagtgagttgagaccacaccaccgcactccagcctgggcaacagagtgagattctttgactaaaa
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate