Basic Information
VIS ID
TVIS30015133
Fusion event
HIV-LACTB integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
63422970/63130771 (Hg38)
End
63423125/63130771 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA15A
Target gene
LACTB
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-mir-6842-3p ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-6778-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-1471 ; hsa-mir-4279 ; hsa-mir-640 ; hsa-mir-4297 ; hsa-mir-5581-5p ; hsa-mir-7107-5p ; hsa-mir-1234-3p ; hsa-mir-1224-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-498 ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-4680-5p ; hsa-mir-4635 ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-891b ; hsa-mir-1306-5p ; hsa-mir-6807-3p ; hsa-mir-217 ; hsa-mir-509-5p ; hsa-mir-509-3-5p ; hsa-mir-4418 ; hsa-mir-129-5p ; hsa-mir-514a-3p ; hsa-mir-514b-3p
Nearest miRNA
hsa-mir-10393/Upstream/306730; hsa-mir-11181/Downstream/740159;
Nearest TSS
ENST00000557528/Upstream/1412; ENST00000558990/Downstream/24944;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/8332, chr15-CpG: 57/Downstream/26448
Upstream sequence
catgatctcacattgcatttacttgtcatatctatcagaagtcacttgacatcagtttgtcccattattgctgatggtattttaatcactttttgaggtg
Downstream sequence
acagtgatggttgtcaaatggtgattttctaattccatcatccattctgtatttatcagttggcattctattataagaaggtgcgggccggggcggtggc
Target sequence
gtgcctgtcaggttattgtaaagttactatttttactttataattaacaagtatatttggaggagataatttgagatgatgtaaaaatcctctttctcatcaaactttctactagttttagcatctatcagtgattcatgactgaatcagttatt
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate