Basic Information
VIS ID
TVIS30015135
Fusion event
HIV-HERC1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
63942897/63650698 (Hg38)
End
63942939/63650698 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA15A
Target gene
HERC1
miRNAs that regulate target gene
hsa-mir-455-3p ; hsa-mir-193b-3p ; hsa-mir-324-3p ; hsa-mir-92a-3p ; hsa-mir-18a-5p
Nearest miRNA
hsa-mir-10393/Upstream/826657; hsa-mir-11181/Downstream/220232;
Nearest TSS
ENST00000557528/Upstream/13148; ENST00000559303/Downstream/24448;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/48986, chr15-CpG: 118/Downstream/182617
Upstream sequence
AGGGCAAAATGGTAGCGTTATAGAAGAGAGTGTAAAGAAAAACACTGAATGTACAAATGTACAAATGTCAAGCACTTAAGTCCTTTCTCAACAATTACTG
Downstream sequence
GCTATTCCTCAAATGTCACACAGAAGTTATTCCTCAAATATGTGACACAGAACACCTATTCCTCAAATATGTAAAAACAAATGAAAATACTAATAAGCTC
Target sequence
ATAACCAAATTGGCATAAGAAACTTACTTGCAGTTAAGGCTA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate