Basic Information
VIS ID
TVIS30015136
Fusion event
HIV-DAPK2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
64230395/63938196 (Hg38)
End
64230445/63938196 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA15A
Target gene
DAPK2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-4263 ; hsa-mir-576-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-4799-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-4509 ; hsa-mir-4744 ; hsa-mir-3667-5p ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-520g-3p ; hsa-mir-135a-5p ; hsa-mir-520h
Nearest miRNA
hsa-mir-10393/Upstream/67177; hsa-mir-11181/Downstream/824191;
Nearest TSS
ENST00000557528/Upstream/9922; ENST00000559061/Downstream/91824;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/103730, chr15-CpG: 72/Downstream/107757
Nearest cancer related gene
DAPK2(TSG, No orient, 0)
Upstream sequence
AtccttctggcactcttttttgatggtttgatgccttgtttctacaactaaattgtaagctctttgagggcagggTTTGTTagagagacaacctggcata
Downstream sequence
gctccactgcctactggttgggttgccttgaacaaggcacctgttggagaaaataattaactctgcttcatgaagccatttggggataattaagacaatg
Target sequence
atgggaagagcacaggctttgctgttggctgtatctgtatttgaatctca
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate