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TVIS30015140
Basic Information
VIS ID
TVIS30015140
Fusion event
HIV-CLPX integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
65454286/65161948 (Hg38)
End
65454101/65161948 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA15A
Target gene
CLPX
miRNAs that regulate target gene
hsa-let-7b-5p
;
hsa-mir-6783-3p
;
hsa-mir-1343-3p
;
hsa-mir-5196-5p
;
hsa-mir-4747-5p
;
hsa-mir-617
;
hsa-mir-4646-5p
;
hsa-mir-204-3p
;
hsa-mir-6742-3p
;
hsa-mir-6852-5p
;
hsa-mir-939-3p
;
hsa-mir-4511
;
hsa-mir-4325
;
hsa-mir-4793-3p
;
hsa-mir-1273g-3p
;
hsa-mir-4538
;
hsa-mir-4453
;
hsa-mir-5089-5p
;
hsa-mir-7151-3p
;
hsa-mir-5095
;
hsa-mir-6778-3p
;
hsa-mir-6804-3p
;
hsa-mir-6506-5p
;
hsa-mir-619-5p
;
hsa-mir-1976
;
hsa-mir-6747-3p
;
hsa-mir-6727-3p
;
hsa-mir-4722-3p
;
hsa-mir-4740-3p
;
hsa-mir-6715b-5p
;
hsa-mir-4269
;
hsa-mir-6504-3p
;
hsa-mir-4438
Nearest miRNA
hsa-mir-10393/Upstream/399433; hsa-mir-11181/Downstream/557298;
Nearest TSS
ENST00000557528/Upstream/6097;
ENST00000566239/Downstream/699;
Nearest CpG islands
None/Target,
chr15-CpG: 55/Upstream/28053
,
chr15-CpG: 99/Downstream/22508
Upstream sequence
TGTAATTTTATTACATGTGATAAATGTCATGCCCAAGTTGGTACACAAGTTATATTCTCATGGCTCATCCTATATATAGTACACTTCAAATAGTGGATAT
Downstream sequence
ATAATACTACTTGGTTCAAAGGCAAATGTAAAAACATCAAACTTAGCTAATTTTCTTTATTTCAATTACTAAAACAAAAGGCCATGTGAATCTTTCTATG
Target sequence
ATTCTATTGCACTTACTGTATTTCTTAATTTTACCACGCATGGTATAATCAGTATTTCTATAAATTTAAAAATAACTGGGGATAATGTAATTTTATTACATGTGATAAATGTCATGCCCAAGTTGGTACACAAGTTATATTCTCATGGCTCATCCTATATATAGTACACTTCAAATAGTGGATAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT1
Sample type
PBMC
Age
47
Gender
Male
CpG Island Information
×
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