Basic Information
VIS ID
TVIS30015142
Fusion event
HIV-DENND4A integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
66070410/65778072 (Hg38)
End
66070239/65778072 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA15A
Target gene
DENND4A
miRNAs that regulate target gene
hsa-mir-92b-3p ; hsa-mir-25-3p
Nearest miRNA
hsa-mir-10393/Upstream/58740; hsa-mir-11181/Downstream/262161;
Nearest TSS
ENST00000557528/Upstream/16635; ENST00000563580/Downstream/14052;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/166740, chr15-CpG: 104/Downstream/13429
Upstream sequence
cagtgagctgagatcaggccaatgcactccagcctgggcgacagagggagactccgtatcaaaaaaaaaaGGCTGTTAAGCTGGTATCTTCAGATATTCC
Downstream sequence
TCAGCACAATAAAATGAAAAATATTCACCAAACAGCAGTTTCAAACAATATTCTATAAATCCAACTTCAGTGTAGTTATGAGTAAGTATGAATAAAATTC
Target sequence
ggatgcacctgtagtcccagctactggaaggctgaggcagaagaatcgcttgaacccggaggcagaggtcgcagtgagctgagatcaggccaatgcactccagcctgggcgacagagggagactccgtatcaaaaaaaaaaGGCTGTTAAGCTGGTATCTTCAGATATTCC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate