Basic Information
VIS ID
TVIS30015151
Fusion event
HIV-ZFAND6 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
80385155/80092813 (Hg38)
End
80385252/80092813 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZFAND6
miRNAs that regulate target gene
hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181d-5p ; hsa-mir-580-5p ; hsa-mir-4262 ; hsa-mir-935 ; hsa-mir-4662a-3p
Nearest miRNA
hsa-mir-10393/Upstream/882942; hsa-mir-11181/Downstream/488290;
Nearest TSS
ENST00000557528/Upstream/17622; ENST00000561017/Downstream/28906;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/32505, chr15-CpG: 58/Downstream/59602
Upstream sequence
GGCAACATTGACACACTATAATACCAATAGAATTTTTAAAAATTGTTTAAATTTGAAGGCTACTCTTAAAAATAGCTATTATTTTGAGCATTTTAATTTT
Downstream sequence
CTGTAAGTTAATATTTAGGCTTTATGTTTAAATATTGGCTACTACAAtttttttttttttttgagacagagtgtcgctctctcacccaggctggaatgca
Target sequence
GTGGTAAAGAAGCAAAAATGTTTCAAATGAATTATATTAAAATACTTTTATATTTAGCTCTCTGAAGAAGTCTTTTGGTCTCAAAATACCCAATTTA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate