Basic Information
VIS ID
TVIS30015156
Fusion event
HIV-IQGAP1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
90935491/90392259 (Hg38)
End
90935584/90392259 (Hg38)
Orient
+
Location type
Intronic
Target gene
IQGAP1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-324-3p ; hsa-mir-92a-3p ; hsa-mir-376a-3p ; hsa-mir-544a ; hsa-mir-136-3p ; hsa-mir-3074-3p ; hsa-mir-449b-3p ; hsa-mir-506-3p ; hsa-mir-506-5p
Nearest miRNA
hsa-mir-10393/Upstream/385418; hsa-mir-1302-10/Downstream/2512140;
Nearest TSS
ENST00000557528/Upstream/3904; ENST00000559682/Downstream/5622;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/3472, chr15-CpG: 166/Downstream/137198
Upstream sequence
TAACCTGTATTTTGCATGCCCTCTTGTGTCTAGGCTTCTTTTCTGAGCTTAAAACTTCCAGGAAACTGGAGCTTGGGTTTCAGTGATGACTTAAGTGAGG
Downstream sequence
AAGAAAACAAAAACTGTAAGATCTCTGCCATTTAAATTGTGGATTTCAAGGTTTGGAAGGTCAAAGAATTTGGAAGCTGCAGCTGTTCTGAGAGACCATC
Target sequence
AGGATAACACTTGTCTTTCTAAATAATAGAAGATGACATAGCAAGGCATGCTATATCACTAGAAAAGGGGGCATTTTCTCATATGAAGTTTAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate