Basic Information
VIS ID
TVIS30015158
Fusion event
HIV-CRTC3 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
91085403/90542171 (Hg38)
End
91085321/90542171 (Hg38)
Orient
-
Location type
Intronic
Target gene
CRTC3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-7-5p ; hsa-mir-671-5p ; hsa-mir-92a-3p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-514b-3p ; hsa-mir-514a-3p ; hsa-mir-29b-2-5p ; hsa-mir-6079 ; hsa-mir-6828-5p ; hsa-mir-4772-5p ; hsa-mir-4487 ; hsa-mir-642b-3p ; hsa-mir-642a-3p ; hsa-mir-29b-1-5p ; hsa-mir-4748 ; hsa-mir-4464 ; hsa-mir-708-5p ; hsa-mir-3139 ; hsa-mir-28-5p ; hsa-mir-129-2-3p ; hsa-mir-129-1-3p ; hsa-mir-383-5p ; hsa-mir-6768-5p ; hsa-mir-93-5p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-10393/Upstream/535330; hsa-mir-1302-10/Downstream/2362228;
Nearest TSS
ENST00000557528/Upstream/2554; ENST00000561290/Downstream/51541;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/11427, chr15-CpG: 72/Downstream/122917
Upstream sequence
ccgtgcgtagccCCCAGGATTCTTTTCATACTGTttttgttttgttttgttttgttttTCTTTGCAACAGTCACAAACTTACACAATACTTGGAAGTATA
Downstream sequence
GTCCACTTAAtttttttttttttttgagaccgagtctcattctgtcgcctaggctggagtgcaatagcgcgatctcagcttactgcaacttccagctcct
Target sequence
ATTCTTTTCATACTGTttttgttttgttttgttttgttttTCTTTGCAACAGTCACAAACTTACACAATACTTGGAAGTATA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate