Basic Information
VIS ID
TVIS30015162
Fusion event
HIV-BLM integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
91334357/90791127 (Hg38)
End
91334507/90791127 (Hg38)
Orient
+
Location type
Intronic
Target gene
BLM
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-215-5p ; hsa-mir-192-5p
Nearest miRNA
hsa-mir-10393/Upstream/784286; hsa-mir-1302-10/Downstream/2113272;
Nearest TSS
ENST00000557528/Upstream/838; ENST00000558825/Downstream/2674;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/73439, chr15-CpG: 19/Downstream/28088
Nearest cancer related gene
BLM(TSG, No orient, 0)
Upstream sequence
ttgtaaaactcaaatgatacagatgtgtacaaggcagaaaatttacaaaccatgccttgtagttttgcccccaaaataactctagttattggtttccttt
Downstream sequence
ccaccaccccatagcctctcttgtctcatccgtcctctcccattagaggcaggcaaatatcttgtatttggtatgtaccttttccAAATGCACATATTTT
Target sequence
gtatcctttcagaccctatttctgcatgcattcttgcatgtaacacatatttcaaacatgcaggaagataaaaaggagaaaataatgagctgtcatatactaccatctggattaagaaataaaacacaatcaatcgagctgaacccctcc
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate