Basic Information
VIS ID
TVIS30015171
Fusion event
HIV-JPT2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
1737202/1687201 (Hg38)
End
1737296/1687201 (Hg38)
Orient
+
Location type
Intronic
Target gene
JPT2
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-9-5p ; hsa-mir-124-3p ; hsa-mir-877-3p ; hsa-mir-125b-2-3p ; hsa-mir-186-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-16-5p ; hsa-mir-188-3p ; hsa-mir-195-5p ; hsa-mir-3138 ; hsa-mir-424-5p ; hsa-mir-4519 ; hsa-mir-4520-3p ; hsa-mir-4691-5p ; hsa-mir-497-5p ; hsa-mir-5193 ; hsa-mir-6791-3p ; hsa-mir-6792-3p ; hsa-mir-6829-3p ; hsa-mir-6838-5p
Nearest miRNA
hsa-mir-3176/Upstream/916924; hsa-mir-11401/Downstream/47784;
Nearest TSS
ENST00000527434/Upstream/1701; ENST00000561765/Downstream/18982;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/8360, chr16-CpG: 104/Downstream/18622
Upstream sequence
cctcctgagtggctgggactacgggcgtatgccaccatgcttaggtaatttttttttgtattttttgtggagacagggtttaaccatgttgcctaggctg
Downstream sequence
TTTGCTGCTTGCCTTTTTTTGGTCTGTTTGGTTGCTTTTTTGGTTGTTAGAGAAATGAGTGTTTCTTATTAAGTGACTAACATTCTCGTTGTTTCCGGTT
Target sequence
gtctcgaactcctgggctcaagccatctgcccacctcggcctctcaaattgctgagattacagacatgcacccttgtgcccggccGAAGCTAGG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate