Basic Information
VIS ID
TVIS30015173
Fusion event
HIV-HAGH integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
1874351/1824350 (Hg38)
End
1874473/1824350 (Hg38)
Orient
+
Location type
Intronic
Target gene
HAGH
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-92b-3p ; hsa-mir-30d-5p
Nearest miRNA
hsa-mir-3176/Upstream/89284; hsa-mir-11401/Downstream/265845;
Nearest TSS
ENST00000527434/Upstream/1446; ENST00000427358/Downstream/2210;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/5054, chr16-CpG: 188/Downstream/1762
Upstream sequence
GCTCTTGAACAGCACGAATCTGAGATATGCACAAAAATCAGCAGTTCCTTTGAGACGGAAAGTTGGCCACAACTGCCCCCAGATTCAAGTGTGGAGGACA
Downstream sequence
ATTTTCAGCAATGAAACTCCTACTAAATCTAAAAATACCTGGGGGCCCCGACAATACCTTCAGTTCCGCTCTACACGGGGAAGAAACCACAGAAGGTGGC
Target sequence
CAAAACCACCATCCAACTGACCCAAAGGACTCTGCCACAGGGGCCCAGAAGGCCCAAGAGCTGGGAGGAGTGGGTGACCAAGGGACAAAAGTGTCTGCCACCCAGTCGACCAATGCAAAAAT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate