Basic Information
VIS ID
TVIS30015174
Fusion event
HIV-TSC2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
2126449/2076448 (Hg38)
End
2126286/2076448 (Hg38)
Orient
-
Location type
Intronic
Target gene
TSC2
miRNAs that regulate target gene
hsa-mir-744-5p ; hsa-mir-296-3p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-3176/Upstream/341382; hsa-mir-11401/Downstream/13747;
Nearest TSS
ENST00000527434/Upstream/292; ENST00000568366/Downstream/956;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/454, chr16-CpG: 17/Downstream/2278
Nearest cancer related gene
TSC2(TSG, No orient, 0)
Upstream sequence
GCATTGAGGGGTGGGAGCTGGGTGCCGCCGCCTTGCCCCTAGCCTGCAGCTTGTCCCTGGCCAGGGGGCACCCGGCAGGCCTGGTGAGGGCCTCCAGCCC
Downstream sequence
CCATTGCCACCCCTCACTGTCTGGGTGTGCTCACTCTGCCAGGGCCTGCGGTCCAATGTCCTCTTGTCTTTTGATGACACCCCCGAGAAGGACAGCTTCA
Target sequence
GGGGCTGTGCCTGTGGCGCTGGGGGCTCTGCTGGGCAGCCTGCAGGGCTTTGATGCGCGGCAGGCATTGAGGGGTGGGAGCTGGGTGCCGCCGCCTTGCCCCTAGCCTGCAGCTTGTCCCTGGCCAGGGGGCACCCGGCAGGCCTGGTGAGGGCCTCCAGCCC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate