Basic Information
VIS ID
TVIS30015181
Fusion event
HIV-DNASE1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
3676180/3626179 (Hg38)
End
3676329/3626179 (Hg38)
Orient
+
Location type
Intronic
Target gene
DNASE1
Nearest miRNA
hsa-mir-1225/Upstream/140710; hsa-mir-11401/Downstream/1045139;
Nearest TSS
ENST00000527434/Upstream/14451; ENST00000570761/Downstream/16701;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/14405, chr16-CpG: 38/Downstream/48164
Nearby gene
SLX4(No orient, 14595)
Upstream sequence
gcagagcaagactctatctcaaaaagggtgtaaagataccacagactagaagatgtgtgtgatgtgcacgggactagtatcatatgcacaatgacaaagg
Downstream sequence
atgaacaaaatgaagataactgctagacaatagctagtgtggtaaggacttcctgtttgagccatggttatttagaagtatgttgcttaatatcaagtgt
Target sequence
attaatatctaaagaaatcctaaaaaaaaaaaaatagaaaaacaggcaagagacttgagtggccaacaggtatatgaagaagtgttcaacttatttagtcaaagaaaatgcaaattaaaccacagtgagtgatcactaaactcagcagc
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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