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VISDB
Viral Integration Site DataBase
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TVIS30015302
Basic Information
VIS ID
TVIS30015302
Fusion event
HIV-MRTFB integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.12
Reference genome
GRCh37/hg19
Start
14310400/14216543 (Hg38)
End
14310321/14216543 (Hg38)
Orient
-
Location type
Intronic
Target gene
MRTFB
miRNAs that regulate target gene
hsa-mir-29c-3p
;
hsa-mir-215-5p
;
hsa-mir-192-5p
;
hsa-mir-607
;
hsa-mir-3156-3p
;
hsa-mir-3671
;
hsa-mir-4433a-5p
;
hsa-mir-3907
;
hsa-mir-3145-3p
;
hsa-mir-139-5p
;
hsa-mir-4735-5p
;
hsa-mir-4301
;
hsa-mir-181a-2-3p
;
hsa-mir-4762-5p
;
hsa-mir-5002-5p
;
hsa-mir-5588-3p
;
hsa-mir-32-3p
;
hsa-mir-6715b-3p
;
hsa-mir-1256
;
hsa-mir-8076
;
hsa-mir-3688-3p
;
hsa-mir-183-5p
;
hsa-mir-190a-5p
;
hsa-mir-190b
;
hsa-mir-19b-3p
;
hsa-mir-19a-3p
Nearest miRNA
hsa-mir-1225/Upstream/1496172; hsa-mir-11401/Downstream/87424;
Nearest TSS
ENST00000527434/Upstream/16213;
ENST00000571770/Downstream/30868;
Nearest CpG islands
None/Target,
chr16-CpG: 29/Upstream/144744
,
chr16-CpG: 54/Downstream/68924
Nearest cancer related gene
MRTFB
(OG, No orient, 0)
Upstream sequence
CAGATGGATGAATTATGGTATTTATAGTTTTACATTGGTTGTACCAATTTTATGCATTTGTAAGTAGATGAGTTGATGCCTGTATACAACCATTAATTAC
Downstream sequence
TGTATATTATAGTTGAATGTTCCTAACAGACACAAGGATATGTATTCAGAAATAAACCCAAATTCTTAATTATGATGACCGACCGAGACACAGGGGATCA
Target sequence
TTATAGTTTTACATTGGTTGTACCAATTTTATGCATTTGTAAGTAGATGAGTTGATGCCTGTATACAACCATTAATTAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Sample Information
×
Sample name
PT1
Sample type
PBMC
Age
47
Gender
Male
CpG Island Information
×
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