Basic Information
VIS ID
TVIS30015321
Fusion event
HIV-UQCRC2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
21977026/21965705 (Hg38)
End
21976925/21965705 (Hg38)
Orient
-
Location type
Intronic
Target gene
UQCRC2
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-23b-3p ; hsa-mir-196a-5p
Nearest miRNA
hsa-mir-1225/Upstream/459570; hsa-mir-11401/Downstream/2237411;
Nearest TSS
ENST00000527434/Upstream/3513; ENST00000567810/Downstream/2757;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/130699, chr16-CpG: 115/Downstream/41961
Upstream sequence
TTTAAGAAATTCAGCGTGCTAGCTTTTTCATCCACCTGCTTTTTAACTAAAATTTTATCTGAACAATTTTTGTGTCTCCTTTAAGAAATGTTTTCATGAC
Downstream sequence
TAAAGGGACATGATCATTACAGAAAAATTAAAAAGTAAAATCAAACAAAATGAAGGGAAAGAAAACATCTCACATACCTAAAGGCACTCAGTGTTAATAC
Target sequence
CTTTAAGAAATTCAGCGTGCTAGCTTTTTCATCCACCTGCTTTTTAACTAAAATTTTATCTGAACAATTTTTGTGTCTCCTTTAAGAAATGTTTTCATGAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate