Basic Information
VIS ID
TVIS30015329
Fusion event
HIV-RBBP6 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
24562540/24551219 (Hg38)
End
24562459/24551219 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA16E
Target gene
RBBP6
miRNAs that regulate target gene
hsa-mir-1254 ; hsa-mir-149-5p ; hsa-let-7b-5p ; hsa-mir-323a-5p ; hsa-mir-876-3p ; hsa-mir-4747-3p ; hsa-mir-1295b-3p ; hsa-mir-5692a ; hsa-mir-548c-3p ; hsa-mir-3129-3p ; hsa-mir-5583-5p ; hsa-mir-6793-3p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-16-2-3p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-195-3p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-3942-5p ; hsa-mir-3944-5p ; hsa-mir-4703-5p ; hsa-mir-6838-5p ; hsa-mir-7856-5p ; hsa-mir-193a-5p ; hsa-mir-1182 ; hsa-mir-520a-3p ; hsa-mir-372-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-302b-3p ; hsa-mir-302c-3p ; hsa-mir-520c-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302a-3p ; hsa-mir-520b ; hsa-mir-373-3p ; hsa-mir-107 ; hsa-mir-103a-3p
Nearest miRNA
hsa-mir-1225/Upstream/347988; hsa-mir-11401/Downstream/1474018;
Nearest TSS
ENST00000527434/Upstream/10636; ENST00000613729/Downstream/1774;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/10840, chr16-CpG: 97/Downstream/178126
Nearby gene
RBBP6(No orient, 1818)
Upstream sequence
ACTAAATATCAGAGTGGTATTTTATAGGATTCTTTAACTTCAAAAAGCTAATATAATTGGCATAAAAGATTTTAGATCCTTGCTTCCCAAAACAAGACCC
Downstream sequence
CTAATTAGGTACAGGGAGGTGGGTTAATTTTAATGTCTACGGTCTGCATCAGTCCGTTTTGTGAGGACTTTAAGTGGCAGACTTTTTTTTACCATTAGTA
Target sequence
TTTTATAGGATTCTTTAACTTCAAAAAGCTAATATAATTGGCATAAAAGATTTTAGATCCTTGCTTCCCAAAACAAGACCC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate