Basic Information
VIS ID
TVIS30015330
Fusion event
HIV-ARHGAP17 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
24992612/24981291 (Hg38)
End
24992461/24981291 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA16E
Target gene
ARHGAP17
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-324-3p ; hsa-mir-320a ; hsa-mir-25-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1225/Upstream/778060; hsa-mir-11401/Downstream/1043946;
Nearest TSS
ENST00000527434/Upstream/3835; ENST00000571219/Downstream/33970;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/250810, chr16-CpG: 66/Downstream/33455
Upstream sequence
AAACAACTGCAAACAATTCAAATAGGAGCTTGGCAGTTGTTAAACAGTTATGAGCACAGTGCTGCAACAGCCacaaagaaaataaagcaaacataaaaac
Downstream sequence
gaggcaagtattaacttcaggaaaaacaaaaagtccactggaaacataaagatagtcatagtaactagtatgctcagctgcaaataattgattggacata
Target sequence
tcccaactccttgctcagtaacctcacactggtacttgaaatcAAAAACATAAACAACTGCAAACAATTCAAATAGGAGCTTGGCAGTTGTTAAACAGTTATGAGCACAGTGCTGCAACAGCCacaaagaaaataaagcaaacataaaaac
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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