Basic Information
VIS ID
TVIS30015342
Fusion event
HIV-PHKB integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
47538351/47504440 (Hg38)
End
47538316/47504440 (Hg38)
Orient
-
Location type
Intronic
Target gene
PHKB
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-484 ; hsa-mir-6882-3p ; hsa-mir-4312 ; hsa-mir-100-3p ; hsa-mir-4258 ; hsa-mir-1265
Nearest miRNA
hsa-mir-1225/Upstream/13340767; hsa-mir-11401/Downstream/2788176;
Nearest TSS
ENST00000527434/Upstream/4684; ENST00000566436/Downstream/89710;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/43144, chr16-CpG: 31/Downstream/739981
Upstream sequence
gtgggtatcctctgtctagcactcaccaaagttccagacatccagaaggaaaccaggtgtgtagtatcaaccatattgttaatgtaaacactttaggttt
Downstream sequence
acatttaggtttagcccctcttgtgagagaatagtggaaaccctttcatgatctgagtgtccacatatcagccaaggggcaaccttacaaacaattcttt
Target sequence
atcaaccatattgttaatgtaaacactttaggttt
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate