Basic Information
VIS ID
TVIS30015353
Fusion event
HIV-RBL2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
53511739/53477827 (Hg38)
End
53511704/53477827 (Hg38)
Orient
-
Location type
Intronic
Target gene
RBL2
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-335-5p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-106a-5p ; hsa-mir-92b-3p
Nearest miRNA
hsa-mir-1225/Upstream/2735450; hsa-mir-11401/Downstream/2767693;
Nearest TSS
ENST00000527434/Upstream/11053; ENST00000564605/Downstream/1719;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/42530, chr16-CpG: 96/Downstream/24762
Nearest cancer related gene
RBL2(TSG, No orient, 0)
Upstream sequence
cctacctcctttgtactgttgtaggcaaatatgttacatttttgtatgttatgggtacattatatatatatattatttatacaattgattttttaatcag
Downstream sequence
ttaagaaaggagaagaaatgtgcagttatactgtatttacgattacataattatctttaccagtgctcttggctttcttcatgtgtagtgttgtccaggg
Target sequence
atatatattatttatacaattgattttttaatcag
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate