Basic Information
VIS ID
TVIS30015359
Fusion event
HIV-CKLF integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q21
Reference genome
GRCh37/hg19
Start
66592761/66558858 (Hg38)
End
66592465/66558858 (Hg38)
Orient
-
Location type
Intronic
Target gene
CKLF
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-215-5p ; hsa-mir-192-5p
Nearest miRNA
hsa-mir-1225/Upstream/8786506; hsa-mir-11401/Downstream/643463;
Nearest TSS
ENST00000527434/Upstream/5463; ENST00000529718/Downstream/4270;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/6042, chr16-CpG: 39/Downstream/7263
Upstream sequence
TGGTCACTAAATGGAAAATCAAACTAATTGGGGAGGCTAAAGTACAATGTTATCTCACTTGAAAATATCTGTAGTTATTACTAAATAATGTTGGCACCTC
Downstream sequence
TTATATTTCATAGTATATAGACTGTAACCTGCCATACTCATATAATTAGGAATAACTGCCCAGTGGAATGCCCAGATGGTTCTGAAAACTGTCAAATTGG
Target sequence
TATCAGTAGATGTGGCTGACGCTTCTGTTAGAATTCACTTGGATAGATCTTCTAAAGAAATTTAAATTTAGGACCATGTTAACAAAATTGTAGTGCATTCTTAATCTTTATTACCTATTTGGATGCATGTTAATATGGCCTCAAAATTGGGATAGAGATGGAGACAGATACACAAGTATCTATCCTTGCACATCTTTGGTCACTAAATGGAAAATCAAACTAATTGGGGAGGCTAAAGTACAATGTTATCTCACT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate