Basic Information
VIS ID
TVIS30015364
Fusion event
HIV-CTCF integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
67622138/67588235 (Hg38)
End
67622259/67588235 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA16B
Target gene
CTCF
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-24-3p ; hsa-mir-1229-3p ; hsa-mir-615-3p ; hsa-let-7b-5p ; hsa-mir-221-3p ; hsa-mir-3662 ; hsa-mir-567 ; hsa-mir-4798-5p ; hsa-mir-6740-5p ; hsa-mir-8088 ; hsa-mir-3140-3p ; hsa-mir-4307 ; hsa-mir-1322
Nearest miRNA
hsa-mir-1225/Upstream/385840; hsa-mir-11401/Downstream/645191;
Nearest TSS
ENST00000527434/Upstream/17457; ENST00000566078/Downstream/22355;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/24584, chr16-CpG: 54/Downstream/56454
Nearest cancer related gene
CTCF(TSG, No orient, 0)
Upstream sequence
ggatgagccactgcgcccagccAGGATCTATATTTTTTAAAGCTCACCAGAATAGGTTTGGGAATCATTGCTCAGGCAGCATCTGTCCAAAATTCATAAA
Downstream sequence
TGATGAAAAGACTGTAGGGCTGCTCCAAAGACGGTCTAACTCTGAGCTGCTTCCAGGGATATGGGTCTGCAGTGTGGCAAGGAGGGATCTGGTGGTCTCT
Target sequence
AGTACCTGTTAGGTGTTGTGTAAATCCTGCATTATGTGTGTGTAGTTTATTCCTATTTTGTAATACATTTATTCAAGGTGATAGACTTGCTATAGATTCTCAGTCTTTCTCCTATTCCAAG
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate