Basic Information
VIS ID
TVIS30015366
Fusion event
HIV-GFOD2 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
67740024/67706121 (Hg38)
End
67740288/67706121 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA16B
Target gene
GFOD2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-421
Nearest miRNA
hsa-mir-1225/Upstream/503726; hsa-mir-11401/Downstream/527305;
Nearest TSS
ENST00000527434/Upstream/20509; ENST00000562633/Downstream/13179;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/38670, chr16-CpG: 60/Downstream/12825
Upstream sequence
acccaggctggagtgcagtagtgcaatctcagctcactgcaacctccgcctccggggttcaagcaattcttctgcctcctgagtagctgggattacagac
Downstream sequence
TCTTTACCCTGCAAGTcacacaaatgcggtaaactgattttcagccaaagcattaaatcaattcaatggggaaaaaaattcttcttaagaaatgatgttg
Target sequence
gcgtgccaccacgcccagctaattttcatattttttgtagagatggggtttcaccacatcggccaggctggtcttgaactcctaaccttgtgagatctgcctgcctcggcctcccaaagtgctgggattacaggtgtgagccactgcgcctggccTGACCATACTTTTTTAAATTACAAAATATGCTTTTTATTTCTCAGTGCTGGGCTTTTAAAAAGAGCCATTAGAGATTTCTATAGACAAAGTTACAGCCTT
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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