Basic Information
VIS ID
TVIS30015374
Fusion event
HIV-SLC7A6 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
68302577/68268674 (Hg38)
End
68302239/68268674 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA16B
Target gene
SLC7A6
miRNAs that regulate target gene
hsa-mir-30a-3p ; hsa-mir-125b-5p ; hsa-mir-375 ; hsa-mir-98-5p ; hsa-mir-193b-3p
Nearest miRNA
hsa-mir-1225/Upstream/35175; hsa-mir-11401/Downstream/1297134;
Nearest TSS
ENST00000527434/Upstream/2072; ENST00000568024/Downstream/4305;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/3598, chr16-CpG: 90/Downstream/41729
Upstream sequence
GAATTGTGATAAATTCATTTATTCCAAAAATTGCTTGTGGCAGTTTCGTGGTTAAATTTTCATGGGGAAATTTTGGTAGTCTGTTAAATTCCTTTATTAC
Downstream sequence
CTGCTGCAGGAGACTGCAGGaatttaaaatttttaaaaatttttttGTTggctgggtgtggtggctcacgcctgtaatcccagcactttgggaagccgag
Target sequence
agaaatgattgcttgttagtggggaaccctccccctccggcatttggtcacagaactcttctgtgttgattattgtggtgtgagagtacacagtaaaaatggttttgagtttttccAAACATTCTCAATAGCATTTTTTCCTTTAGTCATTACAAAAATTTTGGTTTCAAATCCACTTTGTAAAACTTCCTTTGTAATCGAGCTTTTCCCCCCTTTCATCCCGTTTTCTGATGTAATTGAATTGTGATAAATTCA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate