Basic Information
VIS ID
TVIS30015383
Fusion event
HIV-PDPR integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
70164167/70130264 (Hg38)
End
70164229/70130264 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA16B
Target gene
PDPR
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-16-5p ; hsa-let-7b-5p ; hsa-mir-18a-3p ; hsa-mir-544a ; hsa-mir-3907 ; hsa-mir-7106-5p ; hsa-mir-1193 ; hsa-mir-1255b-5p ; hsa-mir-1255a ; hsa-mir-6894-5p ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-6132 ; hsa-mir-6836-5p ; hsa-mir-3605-5p ; hsa-mir-3679-5p ; hsa-mir-1185-5p ; hsa-mir-17-3p ; hsa-mir-1205 ; hsa-mir-1184 ; hsa-mir-3158-5p ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-4756-5p ; hsa-mir-4270 ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-2392
Nearest miRNA
hsa-mir-1225/Upstream/99842; hsa-mir-11401/Downstream/6738672;
Nearest TSS
ENST00000527434/Upstream/10133; ENST00000567896/Downstream/1669;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/15408, chr16-CpG: 69/Downstream/57783
Upstream sequence
tgcctgtaatcccagctacttgagaggctgaggcaggagaattgcttgaacccaggaggcagagagcgagccaagatcgcacgactacactccacccttg
Downstream sequence
CTTTGTCAGTGTTTCTTCTGGGTGGAGAACCTGCTGCACATGCCTTCATTCTGGAACATCAGATGAAACACCAACTCTTTCTTTACCTTGGAACAGGTGT
Target sequence
gcgacaaagcaagactccatctcaaaaataaaataaaaaaataaaTTAAAGCATTGACTTGA
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate