Basic Information
VIS ID
TVIS30015385
Fusion event
HIV-ZNRF1 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
75078944/75045046 (Hg38)
End
75078891/75045046 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZNRF1
miRNAs that regulate target gene
hsa-mir-15b-5p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-4720-3p ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-6746-3p ; hsa-mir-6838-5p ; hsa-mir-4690-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-3194-5p ; hsa-mir-6849-3p ; hsa-mir-4691-3p ; hsa-mir-6858-3p
Nearest miRNA
hsa-mir-1225/Upstream/5014624; hsa-mir-11401/Downstream/1823890;
Nearest TSS
ENST00000527434/Upstream/42749; ENST00000579084/Downstream/50098;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/44737, chr16-CpG: 41/Downstream/69454
Upstream sequence
GCATAATACTTCCACCAGAAGAAGGAGGTGGTAGAGTGTTTGAAATAATTATTGTGTTAGCTGCTGCCCCTGTCCTTTTTCTGTAATGTGGGAAACAAAC
Downstream sequence
TTCGTCTTAGGATCTTCTGGCAGGTGTCCTGGTTGGATCGTGGGTGGTGCTTGTCCGGCTGCCTCAAGGATCCAGCCTAGGGACATGTTCTTTGAGCACT
Target sequence
ATTATTGTGTTAGCTGCTGCCCCTGTCCTTTTTCTGTAATGTGGGAAACAAAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
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