Basic Information
VIS ID
TVIS30015388
Fusion event
HIV-IRF8 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
85951111/85917505 (Hg38)
End
85950843/85917505 (Hg38)
Orient
-
Location type
Intronic
Target gene
IRF8
miRNAs that regulate target gene
hsa-mir-4686 ; hsa-mir-646
Nearest miRNA
hsa-mir-12128/Upstream/175805; hsa-mir-11401/Downstream/842;
Nearest TSS
ENST00000527434/Upstream/3192; ENST00000646214/Downstream/7479;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/18169, chr16-CpG: 24/Downstream/30541
Nearest cancer related gene
IRF8(TSG, No orient, 0)
Upstream sequence
gtgtcacaattggttttcacagcctggactgttactaacatcatgtttttcctcaaatcttaatcttaaaataaaacttaagtttattttaaatgagaac
Downstream sequence
ccactatcattggctgtaaaggaagacctgtggcacctggtataagtaggtaatactgtctggctagaattgattaagattgtatttgtctttcattgaa
Target sequence
CCGGTCTGGGGTACTTAGAAGGAGCTGCAAACTCACTAAGCTCATTGCTAGCGTATGTAATTCTTTTGGTTTAAGGCAATTAAAATGCAGATACCTCCCTGCATTTACATGTTATCTGCATTCCTACCTTAGATTagtgttttccaaactttggtcacttgaggtccagtgtcacaattggttttcacagcctggactgttactaacatcatgtttttcctcaaatcttaatcttaaaataaaacttaagtttat
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate