Basic Information
VIS ID
TVIS30015396
Fusion event
HIV-ZNF276 integration
Validated
Yes
Detection method
LM PCR
Data source
Curated
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Good
Reported year
2014
PubMed ID
24968937
Virus Sequence
Virus name
HIV
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
89799982/89733574 (Hg38)
End
89800048/89733574 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZNF276
miRNAs that regulate target gene
hsa-mir-149-5p ; hsa-mir-92a-3p ; hsa-mir-1303 ; hsa-mir-3149 ; hsa-mir-411-5p ; hsa-mir-4735-5p ; hsa-mir-4775 ; hsa-mir-483-5p ; hsa-mir-590-3p ; hsa-mir-6832-5p
Nearest miRNA
hsa-mir-11401/Upstream/1017237;
Nearest TSS
ENST00000527434/Upstream/325; ENST00000569901/Downstream/4138;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/10893, chr16-CpG: 140/Downstream/82410
Upstream sequence
ATTGCAGGGAGGAGCTTCCCACCATCTACAAGTGTCCTTACCAGGGCTGCACGGCCGTGTACCGAGGCGCTGACGGCATGAAGGTGAGCACTGGCTGTGC
Downstream sequence
TCAGACTTGCGCCCAAGGACACTTTGACCTAGGTTAACCGAGACCTGAAGCAGTCCTAGCCAGTGCCATCCTTGGGGGTAGATGTGAGGCCAGACTTTCA
Target sequence
CTGACCCAGGCCCGGCAGCTGTCAGTGTGAACCTGGGGGAGGTAGCAGGTGTTTCTGCAGCCTAAC
Reference
Maldarelli, F., et al. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science,2014, 345(6193): 179-183.
Curate